Bombali Ebola virus has been detected among bats in Mozambique


In a recent study published in Emerging infectious diseasesresearchers report the detection of Bombali virus (BOMV, of the genus Ebola virus) RNA between three free-tailed strands. mop bits (Molossidae) species of bats in Mozambique.

Study: Bombali Ebolavirus in Mops condylurus Bats (Molossidae), Mozambique.  Image credit: Rudmer Zwerver / Shutterstock
Stady: Bombali Ebolavirus in Mops condylurus Bats (Molossidae), Mozambique. Image credit: Rudmer Zwerver / Shutterstock

background

Studies reported six viral organisms from Ebola virus genus, including Sudan, Zaire, Bundibugyo, Bombali, Tayo Reston Forest), a few of which have caused disease outbreaks with significant mortality on the African continent.

BOMV was initially detected among free-tailed bat species of the Molossidae family, particularly in Sheriff Pomelos And the mop bits Bat species in 2016 in the Bombali region of Sierra Leone.

Two years later, BOMV was identified in mop bits bat species in Kenya and a year later, in Guinea. Studies have not reported cases of infection caused by BOMV in humans, including individuals with symptoms of febrile illness and residing in places where Bombali virus has been detected among bats. BOMV is the only Ebola virus that was repeatedly identified by polymerase chain reaction (PCR) between 2015 and 2019 and among bats located more than 5,000 km apart.

BOMV Epidemiology in MProcesses bite Bats aren’t quite as well known. Seasonal changes in population and environmental changes are key drivers of the transmission dynamics of infectious agents in nature-based environments. For example, the pulses of paramyxovirus, coronavirus and Marburg virus coincided with a seasonal spike in events among bats.

about studying

In this study, researchers detected Bombali virus RNA among three females MProcesses bite Bats were captured in Mozambique at a location southeast of the bats’ geographic range.

In May 2015, 54 samples were obtained mop bits Building bat species in the Inhassoro region of southeastern Mozambique Other bats (n = 211 from 10 other bat species), mostly live in caves. All samples were checked for viruses belonging to coronaviridae, myxoviruses, And the Astroviridae families. RNA was extracted from the samples and subjected to reverse transcription PCR (RT-PCR) analysis.

Complementary DNA was screened using three assays targeting the large protein (L) gene of the family Filoviriridae, and the products of PCR analysis were sequenced. The maps were created using data obtained from the IUCN Red List website and Natural Earth. The Phylogenetic analysis It was performed on the basis of transformation plus evolutionary modeling of gamma. A maximum likelihood tree was constructed based on the partial nucleotide sequence (587 bp) of the L gene of some filoviruses.

consequences

The results of the study reinforced the discovery of the Bombali virus towards the south of the geographical range of l mop bits Bats, a known habitat for bat species. Partial L genome sequencing showed that the BOMV genomic sequences identified in bats from Mozambique were closely related to sequences documented among bats from Kenya, Guinea and Sierra Leone.

The virus was detected in three bats in Guinea between May 2018 and March 2019. In Sierra Leone, the virus was identified in an adult female in May 2016. In Kenya, the virus was detected in an adult female in May 2018 and two adult females. May 2019. In Mozambique, the virus was detected in three females in May 2014.

Although the results were obtained based on a short genome sequence (587 base pairs), they indicated a strong relationship between them. M. condyle and BOMV bats throughout its geographic range. BOMV was only detected in bats of the female sex, with no differences between the adult and sub-adult populations. The team captured most of the BOMV-positive bats in day-to-day areas occupied by livestock or humans.

conclusions

Overall, the results of the study supported the suspicion of this mop bits Bats play a role in maintaining BOMV. Neither Bombali virus nor any other Ebola virus has been identified in humans in Mozambique, highlighting that the study results should not be seen as evidence of a widespread warning to individuals who swell in the local community. However, they should instead motivate the initiation of future studies and the continuation of surveillance efforts.

Additional research should confirm other members of the bat family Molossidae since Bombali virus was first documented in Sheriff Pomelos, and is part of the bat family that frequently roosts at congenital sites, thus creating spillover opportunities. Using a unified single health approach (i.e. multisectoral, multidisciplinary and collaborative) may prevent future disease outbreaks, promote sustainable development of human society, and protect bats with key functional roles in many ecosystems.



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