Plant extracts promising as an alternative to drug therapy – ScienceDaily

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A team of researchers led by the University of California, Irvine discovered that treatment with an extract of rhizomes Rhodiola rosea The plant may be effective to help manage type 2 diabetes, and it shows promise as a safe and effective non-drug alternative.

The study, which was recently published online in Scientific ReportsAnd the found that in a mouse model of human type 2 diabetes, Rhodiola rosea Lowering fasting blood glucose levels, improving response to insulin injections, modulating bacterial composition in the gastrointestinal tract and reducing several biomarkers of inflammation.

“The prevalence of type 2 diabetes and the health costs associated with it have risen steadily in recent decades. Humans have used plants and natural products for thousands of years to treat diseases, our study shows. Rhodiola rosea Corresponding author Dr. Mehtab Jafari, Professor of Pharmaceutical Sciences at UCI, said, “Current treatment recommendations include lifestyle changes in addition to oral and intravenous medications. However, these medications have significant limitations or side effects, which increases the need for interventions A new treatment.

The team used a genetically modified mouse model that develops obesity, insulin resistance and high blood sugar, similar to advanced type 2 diabetes, to test whether Rhodiola rosea It can improve glucose balance. In the study, groups of age-matched male and female mice were randomly divided into one of two groups: the control group, which received water, or the experimental group, which was given Rhodiola rosea extract.

“Our findings indicate that Rhodiola rosea It may be useful in treating type 2 diabetes, as it works through changes in the microbiome that increase the integrity of the gut barrier and reduce the transmission of inflammatory molecules into the circulation. “The integrity of the gut barrier affects body weight and insulin response, and this plant product may improve liver and muscle tissue responses to insulin produced by the pancreas.”

The team’s next steps are to conduct a larger follow-up study in a different mouse model of obesity-induced diabetes to confirm these findings and to investigate the molecular mechanisms involved. In the end, Jafari hopes to do it Rhodiola rosea Clinical trials in patients with type 2 diabetes.

“Our research makes a strong case for the importance of conducting high-quality pre-clinical studies based on sound methodologies to assess the efficacy of standardized plant extracts. We paved the way for human clinical studies, with the ultimate goal of improving health outcomes for patients with type 2 diabetes,” said Al Jaafari.

The team included students and faculty from UCI, UCI Health, and Brigham Young University in Provo, Utah.

This work was supported by the UCI College of Medicine and Pharmaceutical Sciences Collaborative Research Fund and Mr and Mrs. John P. and Lois C. Wareham.

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Materials Introduction of University of California – Irvine. Note: Content can be modified according to style and length.

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