Pregnancies complicated by premature delivery, hypertensive disorders of pregnancy and gestational diabetes are associated with an increased risk of death. – Teach daily

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In Singapore, approximately 15 to 20 percent of pregnancies develop gestational diabetes, 5 to 10 percent of pregnancies are affected by hypertensive disorders of pregnancy, and more than 10 percent of pregnancies end in premature delivery. Pregnancy is a critical reproductive event for women, with major health implications across the lifespan.

This raises an important question: How can pregnancy complications increase women’s long-term risk of death? However, this is often overlooked due to the lack of long-term follow-up data.

With that in mind, Professor Quilin Chang, Director of the Global Center for Asian Women’s Health (GloW) and Professor in the Department of Obstetrics and Gynecology at Yong Lo Lin School of Medicine, National University of Singapore (NUS Medicine), in collaboration with investigators from the University of Pennsylvania and the National Institutes of Health (NIH) , led a research team to investigate the question of how pregnancy complications can lead to long-term risk of death, for those without these complications.

They studied common pregnancy complications as well as overall and cause-specific mortality after more than 50 years of complicated pregnancies. This study was recently published in Rotation.

The study followed more than 45,000 pregnant women in the United States (US), who were enrolled in a pregnancy study during their first pregnancy visit between their 50s and 60s. The researchers recorded common pregnancy complications of preterm labor, gestational hypertensive disorder, and gestational diabetes/impaired glucose tolerance. They followed up with the participants after they loaded the index.

The results showed that those who experienced any of these common complications during pregnancy had an increased risk of dying in the next 50 years after conception. In particular, pregnancies complicated by premature delivery, hypertensive disorders of pregnancy, and gestational diabetes were associated with a 7% to 109%, 9% to 32%, and 14% higher risk of all-cause mortality, respectively.

An interesting finding was that for women who had a preterm birth, the risk of delivery and the cause of death seemed to differ depending on the cause of the preterm birth. The risk of all-cause mortality, which refers to death from any cause, was higher in women who had a cesarean section before delivery.

For cause-specific mortality, premature births due to spontaneous labor have been associated with increased mortality from cardiovascular disease. Premature births from other causes, such as premature membrane rupture and preterm preterm labor, have also been associated with increased mortality from diabetes, kidney and respiratory diseases.

These findings regarding premature births highlight the importance of understanding the causes of premature births when assessing future risks for complications.

“Pregnancy is a stress test early in life for the mother’s basic cardiovascular health, as several major pregnancy complications are associated with an increased risk of high blood pressure, diabetes, and cardiovascular disease, in studies conducted in the United States and Europe. However, no The roles of pregnancy complications on chronic disease and long-term mortality in Asian women are well examined.Thus, studies among Asian women, with continuous, long-term follow-up, are warranted to investigate the roles of pregnancy complications on their later health.Professor Zhang, senior author of the study, said, The development and identification of effective ways to improve the long-term health of women after complicated pregnancies.”

Professor Chang added: “Our study provided compelling evidence to support the notion that promotion of healthy longevity should begin at an early age – a concept that has been increasingly promoted by the NUS Medicine research community.”

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