Study may lead to a new way to treat children with eosinophilic esophagitis

A pioneering study from Ann and Robert H. Getting stuck in the esophagus (feeding tube) for children with this condition. The results were published in the journal Clinical gastroenterology and hepatologyand supported by the CURED Foundation.

EoE is a chronic esophageal disorder of the immune system that affects adults and children with a prevalence of 0.5 to 1 per 1,000. If left untreated, chronic inflammation promotes scarring of the esophagus and the development of esophageal rings and strictures that interfere with its passage. of solid food and can cause an impaction (when food is stuck in the esophagus and cannot be expelled).

The endoscopic functional luminal impedance probe (EndoFLIP) was used in the study to measure the “dilation index,” a functional measure of the amount of force required to stretch the opening of the esophagus. Previously, the extent of scar tissue in the esophagus could only be assessed with the naked eye during endoscopy, making it difficult to detect early changes and intervene before the damage became more extensive.

This is a game changer in how we care for children with EoE. Now, if the distension is low, we can expand the esophagus during the same procedure, and because we can precisely locate the scar, our intervention is more targeted and takes much less time. We’re seeing an improvement in symptoms, which is very exciting.”

Joshua Wechsler, MD, MSCI, senior author, medical director of the Eosinophilic Gastroenterology Program at Lowry Children’s, CURED Investigator at Lowry Children’s, and assistant professor of pediatrics at Northwestern University Feinberg School of Medicine

The research is being conducted at Ann & Robert H. Lurie Children’s Hospital in Chicago through the Stanley Mann Children’s Research Institute. The Manne Research Institute focuses on improving child health, transforming pediatrics, and ensuring a healthier future through the relentless pursuit of knowledge. Lurie Children’s has been rated one of the best children’s hospitals in the country by US News & World Report. It is the pediatric training ground for Northwestern University Feinberg School of Medicine.

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