The National Institutes of Health is now enrolling participants in a landmark initiative to advance nutrition research. Nutrition for Precision Health, Powered by All of Us Research, or NPH, with 14 sites across the United States—including Pennington Biomedical Research Center and LSU Health Sciences New Orleans in Louisiana—to engage 10,000 participants from diverse backgrounds and learn more about how our bodies respond differently to food.
Nutrition for accurate health Brings us one step closer to precision medicine. The study will generate a massive data set, a wealth of biosamples and algorithms that will lead to personalized nutritional recipes that can boost health, prevent heart attacks or strokes, and most importantly, address health disparities.
John Kirwan, PhD, executive director of Bennington Biomedicine
NPH will use AI-based methods to analyze information provided by participants in order to develop algorithms that predict responses to dietary patterns. The results of the study may one day allow healthcare providers to provide personalized dietary guidelines to improve overall health.
“Poor diet is one of the leading causes of preventable disease and death worldwide,” said Holly Nicastro. “If everyone follows the healthy eating guidelines we have now, we may not achieve optimal health because our bodies respond differently to food.” , Ph.D., MPH, NPH Coordinator. “With this study, we look forward to better understanding differences in individual responses and paving the way for more personalized guidance in the future.”
Nutrition is important for the prevention and treatment of most chronic conditions and diseases, including high blood pressure, diabetes, and stroke. However, current dietary recommendations do not take into account individual biological differences in how people respond to foods or the ways and timing of eating. The goal of precision nutrition is to move from a “one size fits all” approach to more specific recommendations based on each individual’s unique characteristics and environments.
“Food lies at the epicenter of health and disease. But clinical nutrition is still limited to a one-size-fits-all approach that often fails a large segment of the population,” said Eric Ravoussin, Ph.D. Co-Executive Director of Clinical Sciences at the Pennington Biomedical Research Center.
NPH will study how a combination of factors, including genes, lifestyle, health history, gut microbiome (the community of microorganisms that live in the human digestive tract), and social determinants of health (the conditions in which people live and work and age affect health) It affects a person’s response to the diet.
To participate in NPH, individuals must be 18 years of age or older and must be registered or already registered with the National Institutes of Health all of us Research programme. all of us It is an effort to engage at least 1 million participants in building a health database that reflects the diversity of the United States, to help accelerate medical research and enable individualized prevention, treatment, and care options.
An NPH study consists of three components. All study participants will participate in the first component, while a subgroup will participate in the other two components. In the first component of the study, participants will be asked to complete surveys, report on their daily diets, and submit blood, urine, and stool samples for laboratory testing, including microbiome analysis. In the second component, a subset of participants will be given diets chosen by the researchers. In the third component, participants will also be given diets chosen by the researchers but will be required to stay in a research center while they follow the diets.
Participants from all three components of the study will participate in meal challenge tests that measure biological changes after they have consumed a standard study-provided meal or beverage. Participants will receive annotated information from the study about their health, including body fat percentage, microbiome makeup, metabolism, and diet composition.
“What we need is accuracy, the ability to prescribe diets that take into account factors that are unique to each person, such as genetics, metabolism, physiology, behavior, and even the microbiota in their bodies,” said Dr. Lianne Redman. Co-Executive Director of Scientific Education at Pennington Biomedical.
NPH will correlate participant data from the study with information obtained through all of us Research program, including genetic information and data from electronic health records and additional surveys. The study will take advantage of advances in artificial intelligence to analyze this vast amount of data from participants to develop algorithms that predict how a person will respond to a particular food or diet based on various factors. All of this data will eventually be accessed through all of us“ Data platform, Researcher Workbench, to support many other studies of health and disease. Strict safeguards are in place to maintain data security and protect participants’ privacy.
“Nutrition is perhaps one of the most powerful medicines we have, but it is among the least understood,” said Jeffrey Ginsburg, MD. all of usMedical and scientific officer. by tapping on all of us Infrastructure and platform, NPH will be distinguished from other nutrition studies by its size and diversity. The value of NPH will be amplified by the research community as new data types are widely made available in the Researcher Workbench to explore and advance our understanding of nutrition and health. “
The National Institutes of Health funded six clinical centers to conduct the study at enrollment sites in different regions of the country. These centers will implement modules of study and engage diverse communities to participate in NPH.
NPH leads multiple institutes and centers within the NIH, including the NIH Joint Fund; all of us research programme; Nutrition Research Office; National Institute of Diabetes and Digestive and Kidney Diseases. National Heart, Lung, and Blood Institute; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Cancer Institute; And the National Center for the Development of Translational Sciences.
Currently, NPH study materials are only available in English. Materials in Spanish will be available at a later date.